ZaroPGx

Pharmacogenomic Analysis Platform

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Upload Genomic File for Analysis
Upload a VCF datafile for pharmacogenomic analysis (currently only GRCh38/hg38 supported.) An index file may be included. Formats FASTQ, BAM, SAM, CRAM, and GRCh37/hg19 VCFs are in testing. Support for BED, 23andMe, and other TXT formats is in development.
Upload
File Upload

Receive and route the uploaded genomic data file(s) for analysis.

Analysis
File Analysis

Inspect and analyze the uploaded file(s), to determine reference, sequencing type, quality, and content. Prepare workflow for the job.

OptiType
OptiType HLA Typing

Perform Human Leukocyte Antigen (HLA) typing with hlatyping, using OptiType. Can be computationally intensive.

GATK
GATK Processing

Genome Analysis Toolkit (GATK) includes functions for filetype conversion and other manipulations. Can be computationally intensive.

PyPGx
PyPGx Star Allele Calling

Call pharmacogenomic star alleles using PyPGx. Additional functions include certain filetype conversions and more.

PharmCAT
PharmCAT Analysis

Call variants and match phenotypes with recommendations. Generate a pharmacogenomic report.

Report
Custom Reports

Generate custom formatted reports with visualizations. When disabled, only PharmCAT's native report is provided.

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Analysis Results
Workflow Details
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ZaroPgx Documentation

ZaroPGx is a free and open source, easily self-hostable individual pharmacogenomic analysis system which attempts to create the most accurate and complete reports possible with a given genomic datafile.

For detailed information, see the software documentation and access the API reference.

Documentation API Reference
About PharmCAT

This platform uses PharmCAT to generate recommendations based on institutional guidelines.
PharmCAT is now part of the ClinPGx project, which includes CPIC and PharmGKB. PharmCAT includes outside calls from hlatyping(OptiType) and PyPGx when available. For a full list of software comprising ZaroPGx, please see the documentation.

Learn More ClinPGx

© 2024-2025 Iliya Yaroshevskiy

This program is licensed under the GNU Affero General Public License v3.0.

Source code: https://github.com/Zaroganos/ZaroPGx. Provided without warranty; see license for details.